After a short period of quiescence, in February 2019, Karymsky volcano (Kamchatka Peninsula, Russia) became active. During the month, a large number of moderate explosions were recorded, some of which were preceded with some periodicity by long-period earthquakes with a high degree of similarity of waveforms. The duration of the multiplet events that preceded the explosions ranged from 4 to 70 minutes. The period between earthquakes decreased as the multiplets developed. The amplitude of earthquake records either increased or remained at the same level. The multiplets with higher amplitude of earthquake records preceded the strongest eruptions. The decreasing period between earthquakes is most likely related to the acceleration of magma ascent and an increase in gas pressure in the volcanic channel. If this is true, the absence of long-period earthquakes after the eruption marks a complete release of gas pressure in the volcanic edifice.