The paper presents geological and geochemical characteristics of Cretaceous guyots of Marcus-Necker intraplate rise in the Pacific Ocean. Comparison of guyots located in different parts of the extended system revealed significant differences in their geochemical characteristics, which suggest lateral and (or) vertical mantle heterogeneity in the region. The studied volcanic rocks belong to the alkaline series. In some cases, they exhibit low values of Na2O/K2O. This volcanism is not typical for most of intraplate ocean rises. No consistency is observed between volcanic rock composition of guyots, their age and (or) geographic position. A complex pattern of magnetic anomaly lineations and irregular location of seamounts of different age cause difficulties in applying hot spot model to explain the formation of this intraplate magmatic province. The location of seamounts in the structure of the rise system and the entire system in the structure of the Pacific Ocean does not contradict the formation of fault zones, which initiate melting of upper mantle geochemically inhomogeneous substrate and lead to the formation of intraplate rises. Deep fluid flows may cause a large-scale melting of the upper mantle.